ARYLTELLUROCHLORINATION OF 4,5-DIARYL-SUBSTITUTED 3-ALLYLTHIO-1,2,4-TRIAZOLES

Thiazolotriazole derivatives have a number of biological activities. Electrophilic intramolecular cyclization unsaturated alkyl 1,2,4-triazole under the action various electrophilic reagents (halogens, tetrahalides chalcogenides) is most effective and simple method synthesis thiazolotriazoles.
 It was previously reported that 3-metalylthio-4,5-diphenyl-1,2,4-triazole reacts with aryltellur-trichloride to form an adduct substrate-electrophile composition 1: 1. Therefore, aim this research study regioselectivity aryltelluriumchlorination allyl thioethers 1,2,4-triazole. found in different solvents 3-allylthio-4-phenyl-5- (3-chlorophenyl) -4H-1,2,4-triazole p-methoxyphenyltellurium trichloride forms molecular similar composition. Instead, addition sodium perchlorate as doping additive reaction medium changes direction leads formation 6-(dichloro-(4-methoxyphenyl)-4-tellanyl) methyl)-5,6-dihydro-3H-thiazolo [3,2- b][1,2,4]triazolium-7.
 Thus, thiazolo[3,2-b][1,2,4]triazolium salts were obtained result aryl telluriumchlorination 4,5-diaryl-substituted 3-allylthio-1,2,4-triazoles. Optimal conditions for proceeding tellurium-induced been found.